abstract：PURPOSE OF REVIEW:The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This re...

journal_title：Current opinion in lipidology

authors： Sánchez-Quesada JL,Benítez S,Ordóñez-Llanos J

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. RECENT FINDINGS:Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the...

journal_title：Current opinion in lipidology

authors： Herz J,Hui DY

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses a syndrome of dyslipidemia and lipodystrophy that has emerged in HIV-infected patients receiving highly active antiretroviral therapy (HAART). The term 'HIV/HAART associated dyslipidemic lipodystrophy (HADL)' describes this syndrome. Although HAART increases patient survival rate...

journal_title：Current opinion in lipidology

authors： Balasubramanyam A,Sekhar RV,Jahoor F,Jones PH,Pownall HJ

更新日期：2004-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions. RECENT FINDINGS:Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory s...

journal_title：Current opinion in lipidology

authors： Leitinger N

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

journal_title：Current opinion in lipidology

authors： Nordestgaard BG,Grønholdt ML,Sillesen H

更新日期：2003-10-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite their pathophysiological importance, the molecular mechanisms and enzymatic components of lipid mobilization from intracellular storage compartments are insufficiently understood. The aim of this review is to evaluate the role of hormone-sensitive lipase in this process. RECENT FINDINGS:Hormo...

journal_title：Current opinion in lipidology

authors： Haemmerle G,Zimmermann R,Zechner R

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeo...

journal_title：Current opinion in lipidology

authors： Michalik L,Desvergne B,Wahli W

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to evaluate recent findings concerning dietary fats and the risk of coronary heart disease. Monounsaturated fatty acids are often regarded as healthy, and many have recommended their consumption instead of saturated fatty acids and polyunsaturated fatty acids. Support for the benefits o...

journal_title：Current opinion in lipidology

authors： Lada AT,Rudel LL

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...

journal_title：Current opinion in lipidology

authors： Freedman SB

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to summarize and discuss recent advances in the understanding of the physiological role of lipoprotein lipase in lipid and energy metabolism. RECENT FINDINGS:Studies on the transcriptional and the posttranscriptional level of lipoprotein lipase expression have provided new i...

journal_title：Current opinion in lipidology

authors： Preiss-Landl K,Zimmermann R,Hämmerle G,Zechner R

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The antioxidant activity of high-density lipoprotein is largely due to the paraoxonase 1 located on it. Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for this enzyme to protect against atherogenesis. This effect of high-density lipoprotein in decreasing low-density li...

journal_title：Current opinion in lipidology

authors： Mackness B,Durrington PN,Mackness MI

更新日期：2002-08-01 00:00:00

abstract：:Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

journal_title：Current opinion in lipidology

authors： Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

更新日期：2002-06-01 00:00:00

abstract：:Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

journal_title：Current opinion in lipidology

authors： Callow MJ,Rubin EM

更新日期：2002-04-01 00:00:00

abstract：:Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

journal_title：Current opinion in lipidology

authors： Rubin J,Berglund L

更新日期：2002-02-01 00:00:00

abstract：:Atherosclerotic cardiovascular disease is the most common complication of diabetes. Recent guidelines in the USA have underlined the importance of treating lipid abnormalities in people with diabetes in order to reduce the risk of this complication. Should lifestyle approaches not be sufficient drugs will need to be a...

journal_title：Current opinion in lipidology

authors： Steiner G

更新日期：2001-12-01 00:00:00

abstract：:New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely inf...

journal_title：Current opinion in lipidology

authors： Plutzky J

更新日期：2001-10-01 00:00:00

abstract：:The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

journal_title：Current opinion in lipidology

authors： Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

更新日期：2001-06-01 00:00:00

abstract：:The mechanism and regulation of the degradation of cholesterol into bile acids has attracted increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently, it has also been shown that the b...

journal_title：Current opinion in lipidology

authors： Björkhem I,Eggertsen G

更新日期：2001-04-01 00:00:00

abstract：:The present review summarizes recent advances in the transcriptional regulation of the human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and signaling mechanisms that affect apolipoprotein gene transcription. An attempt is made to explain how interactions of transcription factors tha...

journal_title：Current opinion in lipidology

authors： Zannis VI,Kan HY,Kritis A,Zanni EE,Kardassis D

更新日期：2001-04-01 00:00:00

abstract：:Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

journal_title：Current opinion in lipidology

authors： Khosla P,Fungwe TV

更新日期：2001-02-01 00:00:00

abstract：:Coronary heart disease is the leading cause of death in the developed world. Current surgical and pharmacological interventions are essentially palliative and interest in preventive strategies, particularly through nutrition and avoidance of tobacco has increased in recent years. Basic scientific, clinical and epidemi...

journal_title：Current opinion in lipidology

authors： Graham IM,O'Callaghan P

更新日期：2000-12-01 00:00:00

abstract：:Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on th...

journal_title：Current opinion in lipidology

authors： Jessup W,Kritharides L

更新日期：2000-10-01 00:00:00

abstract：:The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the major mechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL. The hydrolysis of lipid peroxides by PON1 makes a major co...

journal_title：Current opinion in lipidology

authors： Mackness MI,Durrington PN,Mackness B

更新日期：2000-08-01 00:00:00

abstract：:Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

journal_title：Current opinion in lipidology

authors： Oram JF,Vaughan AM

更新日期：2000-06-01 00:00:00

abstract：:Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...

journal_title：Current opinion in lipidology

authors： Oka K,Davis AR,Chan L

更新日期：2000-04-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：:Recent epidemiological data have reaffirmed that elevated plasma triglyceride and low HDL-cholesterol levels are important risk factors for atherosclerotic vascular disease. The rationale for the clinical use of fibric acid derivatives, which are designed to correct this metabolic nexus, is now on firmer ground. The m...

journal_title：Current opinion in lipidology

authors： Watts GF,Dimmitt SB

更新日期：1999-12-01 00:00:00

abstract：:Atherosclerotic macrovascular disease is the leading cause of both morbidity and mortality in non-insulin dependent diabetes mellitus. Endothelial dysfunction is a key, early and potentially reversible event in pathogenesis of atherosclerosis. Its occurrence in non-insulin dependent diabetes mellitus is well supported...

journal_title：Current opinion in lipidology

authors： Evans M,Khan N,Rees A

更新日期：1999-10-01 00:00:00

abstract：:Further understanding of the causative link between plasma lipids and coronary heart disease will come from a deeper appreciation of the impact of lipoprotein heterogeneity on the processes of atherosclerosis and thrombosis. It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific...

journal_title：Current opinion in lipidology

authors： Packard CJ

更新日期：1999-06-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of 7-dehydrocholesterol). Analysis of the defective gene and identification of mutations therein have paved the way for the study of the molecular genetics of the disor...

journal_title：Current opinion in lipidology

authors： Fitzky BU,Glossmann H,Utermann G,Moebius FF

更新日期：1999-04-01 00:00:00

abstract：:The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

journal_title：Current opinion in lipidology

authors： Cassidy A

更新日期：1999-02-01 00:00:00

abstract：:Recent primary prevention trials demonstrated that cardiovascular morbidity and mortality benefits are not accompanied by adverse effects on overall mortality and morbidity in cohorts representing plasma cholesterol concentrations observed in the bulk of coronary artery disease. During the past year, further analyses ...

journal_title：Current opinion in lipidology

authors： Marais AD

更新日期：1998-12-01 00:00:00

abstract：:The development of atherosclerosis in animal models and the incidence of coronary heart disease in postmenopausal women are markedly reduced by estrogen treatment. Estrogen have acute beneficial effects on vascular reactivity and longer-term effects on critical steps in the pathogenesis of atherosclerosis. Phytoestrog...

journal_title：Current opinion in lipidology

authors： St Clair RW

更新日期：1998-10-01 00:00:00

abstract：:Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...

journal_title：Current opinion in lipidology

authors： Ylä-Herttuala S

更新日期：1998-08-01 00:00:00

abstract：:Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

journal_title：Current opinion in lipidology

authors： de Graaf J,Stalenhoef AF

更新日期：1998-06-01 00:00:00

abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

journal_title：Current opinion in lipidology

authors： Liscum L,Klansek JJ

更新日期：1998-04-01 00:00:00

abstract：:Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

journal_title：Current opinion in lipidology

authors： Verhoef P,Stampfer MJ,Rimm EB

更新日期：1998-02-01 00:00:00

abstract：:Oxidatively damaged LDL may play a critical role in the pathogenesis of atherosclerotic vascular disease. Several pathways promote LDL oxidation in vitro but the physiologically relevant mechanisms have proven difficult to identify. Detection of stable compounds that result from specific reaction pathways has provided...

journal_title：Current opinion in lipidology

authors： Heinecke JW

更新日期：1997-10-01 00:00:00

abstract：:The menopause and its biology are as yet still incompletely understood. Very little is known about biological and molecular changes in cardiovascular target tissues and organs after menopause. Experimental and clinical evidence indicate that prevention of cardiovascular disease by estrogens is aimed both at the correc...

journal_title：Current opinion in lipidology

authors： Soma MR,Baetta R,Crosignani P

更新日期：1997-08-01 00:00:00